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1

Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells

Ben Sahra, I., Laurent, K., Giuliano, S., Larbret, F., Ponzio, G., Gounon, P., Le Marchand-Brustel, Y., Giorgetti-Peraldi, S., Cormont, M., Bertolotto, C., Deckert, M., Auberger, P., Tanti, J.-F., Bos

Journal:

Cancer Research

Year:

2010

Language:

english

File:

PDF, 617 KB

english, 2010

2

Les stéatopathies métaboliques : conséquences hépatiques du syndrome métabolique

Rodolphe Anty, Philippe Gual, Pierre-Michel Huet, Yannick Le Marchand-Brustel, Albert Tran

Journal:

Gastroentérologie Clinique et Biologique

Year:

2007

Language:

french

File:

PDF, 302 KB

french, 2007

3

Metformin in Cancer Therapy: A New Perspective for an Old Antidiabetic Drug?

Ben Sahra, I., Le Marchand-Brustel, Y., Tanti, J.-F., Bost, F.

Journal:

Molecular Cancer Therapeutics

Year:

2010

Language:

english

File:

PDF, 303 KB

english, 2010

4

1274 MORBIDLY OBESE PATIENTS WITH ALANINE AMINOTRANSFERASE (ALT) LEVEL BELOW THE THRESHOLD 0.5 TIMES THE UPPER LIMIT OF NORMAL HAVE NO NASH

Anty, R., Iannelli, A., Patouraux, S., Bonnafous, S., Lavallard, V., Marine-Barjoan, E., Schneck, A.-S., Paul, M.C. Saint, Huet, P.M., Marchand-Brustel, Y. Le, Gugenheim, J., Gual, P., Tran, A.

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 61 KB

english, 2012

5

CD2AP/CMS Regulates Endosome Morphology and Traffic to the Degradative Pathway Through its Interaction with Rab4 and c-Cbl

Mireille Cormont, Isidoro Metón, Muriel Mari, Pascale Monzo, Frédérique Keslair, Chantell Gaskin, Timothy E. McGraw, Yannick Le Marchand-Brustel

Journal:

Year:

2003

Language:

english

File:

PDF, 799 KB

english, 2003

6

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 : Potential involvement of Src kinase

Sophie Grillo, Thierry Grémeaux, Antonio Casamayor, Dario R Alessi, Yannick Le Marchand-Brustel, Jean-François Tanti

Journal:

Year:

2000

Language:

english

File:

PDF, 451 KB

english, 2000

7

Photoaffinity labelling of the insulin receptor in intact rat hepatocytes, mouse soleus muscle, and cultured human lymphocytes

M. Fehlmann, Y. Le Marchand-Brustel, E. Van Obberghen, D. Brandenburg, P. Freychet

Journal:

Year:

1982

Language:

english

File:

PDF, 804 KB

english, 1982

8

Hypoglycaemia induced by antibodies to insulin receptor following a bone marrow transplantation in an immunodeficient child

N. Rochet, S. Blanche, J. C. Carel, A. Fischer, F. L. Deist, C. Griscelli, E. Van Obberghen, Y. Le Marchand-Brustel

Journal:

Year:

1989

Language:

english

File:

PDF, 862 KB

english, 1989

9

Effect of work-induced hypertrophy on muscle glucose metabolism in lean and obese mice

G. Augert, G. Van de Werve, Y. Le Marchand-Brustel

Journal:

Year:

1985

Language:

english

File:

PDF, 786 KB

english, 1985

10

GTPase activating protein activity for Rab4 is enriched in the plasma membrane of 3T3-L1 adipocytes. Possible involvement in the regulation of Rab4 subcellular localization

M. -N. Bortoluzzi, M. Cormont, N. Gautier, E. Van Obberghen, Y. Le Marchand-Brustel

Journal:

Year:

1996

Language:

english

File:

PDF, 1.05 MB

english, 1996

11

Autoantibodies to the insulin receptor are infrequent findings in Type 1 (insulin-dependent) diabetes mellitus of recent onset

N. Rochet, J. L. Sadoul, B. Ferrua, J. Kubar, J. F. Tanti, P. Bougnères, B. Vialettes, E. Van Obberghen, Y. Le Marchand-Brustel, P. Freychet

Journal:

Year:

1990

Language:

english

File:

PDF, 665 KB

english, 1990

12

Alterations in insulin signalling pathway induced by prolonged insulin treatment of 3T3-L1 adipocytes

J. -M. Ricort, J. -F. Tanti, E. Van Obberghen, Y. Le Marchand-Brustel

Journal:

Year:

1995

Language:

english

File:

PDF, 1.08 MB

english, 1995

13

Insulin receptor dephosphorylation by phosphotyrosine phosphatases obtained from insulin-resistant obese mice

C. Olichon-Berthe, S. Hauguel -De Mouzon, P. Péraldi, E. Van Obberghen, Y. Le Marchand-Brustel

Journal:

Year:

1994

Language:

english

File:

PDF, 504 KB

english, 1994

14

Effect of exercise on protein turnover in muscles of lean and obese mice

G. Augert, S. Monier, Y. Le Marchand-Brustel

Journal:

Year:

1986

Language:

english

File:

PDF, 723 KB

english, 1986

15

Effect of an α-glycosidase inhibitor on experimentally-induced obesity in mice

Y. Le Marchand-Brustel, N. Rochet, T. Grémeaux, I. Marot, E. Van Obberghen

Journal:

Year:

1990

Language:

english

File:

PDF, 798 KB

english, 1990

16

Anti-insulin receptor antibodies inhibit insulin binding and stimulate glucose metabolism in skeletal muscle

Y. Le Marchand-Brustel, P. Gorden, J. S. Flier, C. R. Kahn, P. Freychet

Journal:

Year:

1978

Language:

english

File:

PDF, 700 KB

english, 1978

17

Studies on the mechanism of insulin resistance after injury in the mouse

K. N. Frayn, Y. Le Marchand-Brustel, P. Freychet

Journal:

Year:

1978

Language:

english

File:

PDF, 525 KB

english, 1978

18

Somatostatin in the pancreas and hypothalamus of obese mice

J. Dolais-Kitabgi, Y. Le Marchand-Brustel, P. Freychet

Journal:

Year:

1979

Language:

english

File:

PDF, 460 KB

english, 1979

19

MAP kinases and mTOR mediate insulin-induced phosphorylation of Insulin Receptor Substrate-1 on serine residues 307, 612 and 632

P. Gual, T. Grémeaux, T. Gonzalez, Y. Le Marchand-Brustel, J.-F. Tanti

Journal:

Year:

2003

Language:

english

File:

PDF, 430 KB

english, 2003

20

Differential effects of IRS1 phosphorylated on Ser307 or Ser632 in the induction of insulin resistance by oxidative stress

A. Bloch-Damti, R. Potashnik, P. Gual, Y. Le Marchand-Brustel, J. F. Tanti, A. Rudich, N. Bashan

Journal:

Year:

2006

Language:

english

File:

PDF, 555 KB

english, 2006

21

Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans

V. Kaddai, J. Jager, T. Gonzalez, R. Najem-Lendom, S. Bonnafous, A. Tran, Y. Le Marchand-Brustel, P. Gual, J.-F. Tanti, M. Cormont

Journal:

Year:

2009

Language:

english

File:

PDF, 231 KB

english, 2009

22

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity

J. Jager, V. Corcelle, T. Grémeaux, K. Laurent, A. Waget, G. Pagès, B. Binétruy, Y. Le Marchand-Brustel, R. Burcelin, F. Bost, J. F. Tanti

Journal:

Year:

2011

Language:

english

File:

PDF, 456 KB

english, 2011

23

A new composite model including metabolic syndrome, alanine aminotransferase and cytokeratin-18 for the diagnosis of non-alcoholic steatohepatitis in morbidly obese patients

R. Anty, A. Iannelli, S. Patouraux, S. Bonnafous, V. J. Lavallard, M. Senni-Buratti, I. Ben Amor, A. Staccini-Myx, M.-C. Saint-Paul, F. Berthier, P.-M. Huet, Y. Le Marchand-Brustel, J. Gugenheim, P. G

Journal:

Alimentary Pharmacology & Therapeutics

Year:

2010

Language:

english

File:

PDF, 202 KB

english, 2010

24

Rab proteins in endocytosis and Glut4 trafficking

V. Kaddai, Y. Le Marchand-Brustel, M. Cormont

Journal:

Acta Physiologica

Year:

2008

Language:

english

File:

PDF, 697 KB

english, 2008

25

Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice

Le Marchand-Brustel, Yannick, Grémeaux, Thierry, Ballotti, Robert, Van Obberghen, Emmanuel

Journal:

Year:

1985

File:

PDF, 523 KB

1985

26

10.1038/35050135

Thomas, George, Pende, Mario, Kozma, Sara C., Jaquet, Muriel, Oorschot, Viola, Burcelin, Rémy, Le Marchand-Brustel, Yannick, Klumperman, Judith, Thorens, Bernard

Journal:

Year:

2000

Language:

english

File:

PDF, 270 KB

english, 2000

27

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

Sahra, I Ben, Laurent, K, Loubat, A, Giorgetti-Peraldi, S, Colosetti, P, Auberger, P, Tanti, J F, Le Marchand-Brustel, Y, Bost, F

Journal:

Year:

2008

Language:

english

File:

PDF, 320 KB

english, 2008

28

Insulin-like growth factor-I-stimulated glucose transport in myotubes derived from chicken muscle satellite cells

Duclos, M. J., Chevalier, B., Le Marchand-Brustel, Y., Tanti, J. F., Goddard, C., Simon, J.

Journal:

Journal of Endocrinology

Year:

1993

Language:

english

File:

PDF, 2.34 MB

english, 1993

29

Rosiglitazone increases cell surface GLUT4 levels in 3T3-L1 adipocytes through an enhancement of endosomal recycling

Laurène Martinez, Marion Berenguer, M. Christine Bruce, Yannick Le Marchand-Brustel, Roland Govers

Journal:

Biochemical Pharmacology

Year:

2010

Language:

english

File:

PDF, 537 KB

english, 2010

30

GLUT4 molecules are recruited at random for insertion within the plasma membrane upon insulin stimulation

Marion Berenguer, Yannick Le Marchand-Brustel, Roland Govers

Journal:

Year:

2010

Language:

english

File:

PDF, 626 KB

english, 2010

31

CA59 - La protéine C réactive est augmentée dans le foie et dans le tissu adipeux chez les malades obèses sévères, indépendamment de la présence d’un diabète ou d’une nash

R. Anty, P. Gual, S. Bekri, N. Luciani, M.C. Saint-Paul, M. Dahman, A. Iannelli, I. Ben Amor, A. Staccini-Myx, P.M. Huet, J. Gugenheim, J.L. Sadoul, Y. Le Marchand-Brustel, A. Tran

Journal:

Gastroentérologie Clinique et Biologique

Year:

2005

Language:

french

File:

PDF, 183 KB

french, 2005

32

CA 26-Ostéopontine : un nouvel acteur potentiel hépatique des maladies de surcharge graisseuse

R. Anty, A. Bertola, M.C. Saint-Paul, M. Dahman, J. Gugenheim, J.L. Sadoul, P.M. Huet, Y. Le Marchand-Brustel, A. Tran, P. Gual

Journal:

Gastroentérologie Clinique et Biologique

Year:

2006

Language:

french

File:

PDF, 55 KB

french, 2006

33

CO 6-L’hepcidine est exprimée dans le tissu adipeux et son expression est augmentée chez les malades sévèrement obèses indépendamment du diabète et de la stéatohépatite non alcoolique (NASH)

P. Gual, S. Bekri, R. Anty, N. Luciani, M. Dahman, B. Ramesh, M.C. Saint-Paul, P.M. Huet, J.L. Sadoul, J. Gugenheim, S.K.S. Srai, Y. Le Marchand-Brustel, A. Tran

Journal:

Gastroentérologie Clinique et Biologique

Year:

2006

Language:

french

File:

PDF, 47 KB

french, 2006

34

Polymxin B inhibits insulin-induced glucose transporter and IGF II receptor translocation in isolated adipocytes

Mireille CORMONT, Thierry GREMEAUX, Jean-François TANTI, Emmanuel VAN OBBERGHEN, Yannick LE MARCHAND-BRUSTEL

Journal:

Year:

1992

Language:

english

File:

PDF, 1.03 MB

english, 1992

35

Rab4 is phosphorylated by the insulin-activated extracellular-signal-regulated kinase ERK1

Mireille CORMONT, Jean-François TANTI, Ahmed ZAHRAOUI, Emmanuel VAN OBBERGHEN, Yannick LE MARCHAND-BRUSTEL

Journal:

Year:

1994

Language:

english

File:

PDF, 751 KB

english, 1994

36

Different Effects of Insulin and Platelet-Derived Growth Factor on Phosphatidylinositol 3-Kinase at the Subcellular Level in 3T3-L1 Adipocytes : A Possible Explanation for Their Specific Effects on Glucose Transport

Jean-Marc Ricort, Jean-François Tanti, Emmanuel Van Obberghen, Yannick Le Marchand-Brustel

Journal:

Year:

1996

Language:

english

File:

PDF, 784 KB

english, 1996

37

Insulin activates glycogen synthase in phosphorylase kinase deficient mice

Yannick Le Marchand-Brustel, Patricia T.W. Cohen, Philip Cohen

Journal:

Year:

1979

Language:

english

File:

PDF, 354 KB

english, 1979

38

Alteration of glycogen synthase activation by insulin in soleus muscles of obese mice

Yannick Le Marchand-Brustel, Pierre Freychet

Journal:

Year:

1980

Language:

english

File:

PDF, 327 KB

english, 1980

39

Insulin affects only initiation and not elongation in protein synthesis in soleus muscles of lean and obese mice

Solange Monier, Yannick Le Marchand-Brustel

Journal:

Year:

1982

Language:

english

File:

PDF, 322 KB

english, 1982

40

Parallel changes in Glut 4 and Rab4 movements in two insulin-resistant states

Jean-Marc Ricort, Jean-François Tanti, Mireille Cormont, Emmanuel Van Obberghen, Yannick Le Marchand-Brustel

Journal:

Year:

1994

Language:

english

File:

PDF, 249 KB

english, 1994

41

Effect of insulin and insulin-like growth factor-1 on glucose transport and its transporters in soleus muscle of lean and obese mice

Y. Le Marchand-Brustel, S.J. Heydrick, D. Jullien, N. Gautier, E. Van Obberghen

Journal:

Year:

1995

Language:

english

File:

PDF, 566 KB

english, 1995

42

The formation of an intrachain disulfide bond in the leptin protein is necessary for efficient leptin secretion

N. Boute, V. Zilberfarb, L. Camoin, S. Bonnafous, Y. Le Marchand-Brustel, T. Issad

Journal:

Year:

2004

Language:

english

File:

PDF, 298 KB

english, 2004

43

Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

Philippe Gual, Yannick Le Marchand-Brustel, Jean-François Tanti

Journal:

Year:

2005

Language:

english

File:

PDF, 382 KB

english, 2005

44

Dimethyl sulfoxide enhances GLUT4 translocation through a reduction in GLUT4 endocytosis in insulin-stimulated 3T3-L1 adipocytes

Marion Berenguer, Jinzhong Zhang, M. Christine Bruce, Laurène Martinez, Teresa Gonzalez, Andrey A. Gurtovenko, Tao Xu, Yannick Le Marchand-Brustel, Roland Govers

Journal:

Year:

2011

Language:

english

File:

PDF, 1.67 MB

english, 2011

45

C-reactive protein levels in relation to various features of non-alcoholic fatty liver disease among obese patients

Esther Zimmermann, Rodolphe Anty, Joan Tordjman, An Verrijken, Philippe Gual, Albert Tran, Antonio Iannelli, Jean Gugenheim, Pierre Bedossa, Sven Francque, Yannick Le Marchand-Brustel, Karine Clement,

Journal:

Journal of Hepatology

Year:

2011

Language:

english

File:

PDF, 717 KB

english, 2011

46

Reply to: “C-reactive protein levels in non-alcoholic fatty liver disease”

Tine Jess, Esther Zimmermann, Rodolphe Anty, Joan Tordjman, An Verrijken, Philippe Gual, Albert Tran, Antonio Iannelli, Jean Gugenheim, Pierre Bedosa, Sven Francque, Yannick Le Marchand-Brustel, Karin

Journal:

Journal of Hepatology

Year:

2012

Language:

english

File:

PDF, 220 KB

english, 2012

47

Presence of an insulin-stimulated serine kinase in cell extracts from IM-9 cells

Robert Ballotti, Aline Kowalski, Y. Le Marchand-Brustel, Emmanuel Van Obberghen

Journal:

Biochemical and Biophysical Research Communications

Year:

1986

Language:

english

File:

PDF, 723 KB

english, 1986

48

Potential role of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in insulin-stimulated glucose transporter 4 translocation in adipocytes

Sophie Grillo, Thierry Grémeaux, Yannick Le Marchand-Brustel, Jean-François Tanti

Journal:

Year:

1999

Language:

english

File:

PDF, 90 KB

english, 1999

49

670 Morbidly obese patients with or whitout nash and type 2 diabetes have increased inflammatory C-reactive protein in both liver and adipose tissue

R. Anty, S. Bekri, N. Luciani, M.C. Saint Paul, M. Dahman, A. Iannelli, I. Ben Amor, A. Staccini-Myx, P.M. Huet, J. Gugenheim, J.L. Sadoul, Y. Le Marchand-Brustel, A. Tran, P. Guall

Journal:

Journal of Hepatology

Year:

2006

Language:

english

File:

PDF, 268 KB

english, 2006

50

93 C-REACTIVE PROTEIN INHIBITS INSULIN SIGNALLING PATHWAY IN BOTH HUMAN HEPATOCYTES AND ADIPOCYTES

A. Bertola, R. Anty, S. Bonnafous, Y. Le Marchand-Brustel, A. Tran, P. Gual

Journal:

Journal of Hepatology

Year:

2008

Language:

english

File:

PDF, 61 KB

english, 2008

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